SAN DIEGO — Calamity followed the San Diego Padres home.

A day after losing a five-run lead in the eighth inning in Colorado, the Padres went down big early and lost 9-3 to the Philadelphia Phillies on Friday night at Petco Park.

The Phillies battered Joe Musgrove from the start, with Kyle Schwarber leading off the game with a high fly ball that landed on the other side of the right field wall and Bryce Harper, Brandon Marsh and Nick Castellanos hitting no-doubt homers in the third inning.

The four home runs were the most Musgrove had ever allowed in a game.

The Phillies also scored in the first inning on a pair of doubles and preceded one of the third-inning homers with a double. Not until their eighth hit, with one out in the fourth inning, did they have a single.

Where Friday certainly justified some concern about Musgrove’s health — or at least about the lack of consistency from one of the team’s most crucial pieces — it could have been worse in the short term.

The Padres bullpen had to cover 61/3 innings in Thursday’s 10-9 loss to the Colorado Rockies after Randy Vásquez could not make it through the third.

Musgrove, who had turned in quality starts in his previous two starts, was able to get into the fourth on Friday, and Jeremiah Estrada covered 21/3 innings after him before Tom Cosgrove and Stephen Kolek finished the game.

Padres manager Mike Shildt tried to hold off as long as he could. No matter how much the Padres believe they can come back from any deficit, they were facing Aaron Nola, who entered the game having allowed a total of five runs in his previous four starts.

The priority once the Phillies went up 6-0 was surviving the night while burning through as few arms as possible.

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